Research progress on the immunomodulatory effects of mes-enchymal stem cells and their extracellular vesicles in the treat-ment of liver failure
Bin Niu1
Jun Xu2
Liaoyun Zhang1
1.Department of Infectious Diseases,First Hospital of Shanxi Medical University,Taiyuan,Shanxi,China2.Department of Hepatobiliary and Pancreatic Surgery,First Hospital of Shanxi Medical University,Taiyuan,Shanxi,China
摘要：Liver failure is a critical and life-threatening condition in hepatology,challenging management,limited therapeu-tic options,and generally poor prognosis.For the treatment of liver failure,mesenchymal stem cells(MSCs)and mesenchymal stem cell-derived extracellular vesicles(MSCs-EVs)offer promising prospects.This article provides an overview and immunological characteristics of MSCs and MSCs-EVs,explains the immunological imbalance in liver failure,details the immunological mechanisms of MSCs and MSCs-EVs in treating liver failure,and dis-cusses their potential application and key issues.It aims to provide valuable insight for basic research and clinical application of MSCs/MSCs-EVs in liver failure.
机标关键词：researchstemcellseffectsextracellularfailureimmunomodulatorliver
论文发表日期：2024-03-30
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：9( 17-25 )
英文信息