Role of Fc-mediated Ab functions in HIV and SARS-Cov-2 vac-cine prevention
Li-Yun Lin1
Aiwei Zhu2
Bin Su2
Christiane Moog3
1.Laboratoire d'Immuno-Rhumathologie Moléculaire,Institut national de la santé et de la recherche médicale(INSERM)UMR_S 1109,Institut thématique interdisciplinaire(ITI)de Médecine de Précision de Strasbourg,Transplantex NG,Faculté de Médecine,Fédération Hospitalo-Universitaire OMICARE,Fédération de Médecine Translationnelle de Strasbourg(FMTS),Université de Strasbourg,Strasbourg,France2.Beijing Key Laboratory for HIV/AIDS Research,Clinical and Research Center for Infectious Diseases,Beijing Youan Hospital,Capital Medical University,Beijing,China;Sino-French Joint Laboratory for HIV/AIDS Research,Sino-French Joint Laboratory for Research on Humoral Immune Response to HIV Infection,Beijing Youan Hospital,Capital Medical University,Beijing,China3.Laboratoire d'Immuno-Rhumathologie Moléculaire,Institut national de la santé et de la recherche médicale(INSERM)UMR_S 1109,Institut thématique interdisciplinaire(ITI)de Médecine de Précision de Strasbourg,Transplantex NG,Faculté de Médecine,Fédération Hospitalo-Universitaire OMICARE,Fédération de Médecine Translationnelle de Strasbourg(FMTS),Université de Strasbourg,Strasbourg,France;Sino-French Joint Laboratory for HIV/AIDS Research,Sino-French Joint Laboratory for Research on Humoral Immune Response to HIV Infection,Beijing Youan Hospital,Capital Medical University,Beijing,China;Vaccine Research Institute(VRI),Créteil,France
摘要：The purpose of vaccination is to generate Neutralizing antibodies(NAbs),as these antibodies have neutralizing activ-ity against viral infections such as HIV and SARS-CoV-2.NAb has high antiviral potency and therefore be served as therapeutics.However,induction of NAb is not easy,and RNA viruses such as HIV and SARS-CoV-2 always escape NAb binding epitopes due to the rapid mutation of their genomes.Thus,despite Fab and neutralizing,other compo-nent and its function against viral infection is important in the biology of antibodies,such as the Fc part in antibodies.Fc-mediated function showed protective potency in viral infection.Fc-mediated ADCC contributes to protect against HIV in phase II/III clinical trial,but remains controversy.Marginal evidences show protectivity of non-NAb and Fc-mediated ADCC in HIV infection and AIDS progress.In SARS-CoV-2 infection,Fc-mediated ADCC showed po-tent antiviral activity as well.While,the participation of non-NAb is elusive in the control of HIV and SARS-CoV-2 dual infection.Limited data reported that Fc-mediated functions is regulated following HIV infection as people living with HIV after vaccination of pulmonary pathogens display increased ADCC activity to homologues pathogens.In order to reveal Fc-mediated function,there is a need to actively develop a robust and accurate in vitro assay to mea-sure it.This is an emerging attract that have drawn much attention.
机标关键词：sars-cov-2rolefc-mediatedfunctionspreventionvac-cine
论文发表日期：2024-03-30
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：6( 26-31 )
英文信息