Analysis of Factors Influencing Plasma Concentration of Rifam-picin in Patients with Pulmonary Tuberculosis

Jia Zhou; Ai-Xian Huang; Hong-Fa Tan; Yu-Ting Ma; Yan Liang; Chun-Xiong Su

摘要：Objective To analyze the factors influencing the rifampicin blood concentration in patients with tuberculosis and provide a scientific basis for clinical physicians to formulate anti-tuberculosis treatment plans. Methods In total,183 inpatients with pulmonary tuberculosis treated at Nanning Fourth People's Hospital from July 2021 to April 2023 were divided into 4 groups:the standard treatment group(n=92),tuberculosis with HIV co-infection group(n=26),hemodialysis group(n=63),and co-infection with hemodialysis group(n=2).The plasma drug concentrations and influencing factors in each group were analyzed at 2,4,and 6 hours after adminis-tration of rifampicin.According to the peak rifampicin plasma concentration(8-24 µg/mL)at 6 hours,the patients were also divided into a low-concentration group(<8 µg/mL)and normal-concentration group(≥8 µg/mL).Bina-ry logistic regression was used to analyze the factors influencing the rifampicin plasma concentration. Results There was a statistically significant difference in the rifampicin plasma concentration among the groups at 6 hours(P<0.05),but not at 2 and 4 hours(P>0.05).Univariate analysis showed that the urea nitrogen level,creatinine level,dose administered,and hemodialysis affected the rifampicin plasma concentration(P<0.05).Bi-nary logistic regression analysis showed that the administered dose was positively correlated with the rifampicin plasma concentration(odds ratio,4.591;95%confidence interval,1.494-14.103).However,multivariate analysis showed that age,urea nitrogen level,creatinine level,HIV infection,and hemodialysis did not have a significant effect on the rifampicin plasma concentration(P>0.05). Conclusion The influencing factors,including hemodialysis,discussed in this article have little effect on the ri-fampicin plasma concentration in patients with tuberculosis.Patients undergoing maintenance hemodialysis can take rifampicin before the procedure without the need to increase the dosage.