Therapeutic effect of Nanyang kiwifruit extract on oral ulcer
Tao Liu1
Xintong Nie2
Wenjuan Du3
Rui Xiao4
1.Department of Stomatology,the Sixth Medical Center of PLA General Hospital,Beijing 100048,China2.Dali University School of Public Health,Dali 671003,China3.Medical Innovation Research Division,The First Medical Center of PLA General Hospital,Beijing 100853,China4.Department of Stomatology,the First Medical Center of PLA General Hospital,Beijing 100853,China
摘要：Objective This study aimed to examine the pharmacodynamic effects of Nanyang kiwifruit extract on rats with traumatic oral ulcers and to provide a theoretical basis for its potential clinical application in treating oral mucosal diseases.
Methods Fifty-four male Sprague Dawley rats were acclimatized for 1 week before being subjected to chemi-cal cauterization to induce oral ulcers.The rats were then divided into six groups:the control group,the model group,Nanyang kiwifruit extract/hydroxyapatite group,the hydroxyapatite group,the ordinary kiwifruit ex-tract group,and Nanyang kiwifruit extract group.The evaluation indicators included the state of ulcer healing,the ulcer area,and the healing period.To assess the pathology of the wounds,three rats from each group were randomly selected on the third and fifth days of drug administration for hematoxylin and eosin(HE)staining.
Results Compared with the other groups,Nanyang kiwifruit extract and Nanyang kiwifruit extract/hydroxyapa-tite group demonstrated a significant reduction in the healing time of oral ulcers,as evidenced by both observation and the HE staining results.The HE staining further revealed that the mucosal epithelium healed more rapidly and the edema recovered faster in the Nanyang kiwifruit extract group and Nanyang kiwifruit extract/hydroxyapatite group than in the other groups.These findings indicate that the Nanyang kiwifruit extract group and Nanyang ki-wifruit extract/hydroxyapatite group had a pronounced effect on promoting ulcer healing.
Conclusion Nanyang kiwifruit extract and the hydroxyapatite effectively promote ulcer healing and reduce the healing time of oral ulcer wounds.
机标关键词：oraleffectextractkiwifruitnanyangtherapeuticulcer
论文发表日期：2025-03-30
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：11( 37-47 )
英文信息