Predictive value of inflammatory factors and coagulation function for abdominal infection in patients with liver cirrhosis and ascites

Wenjing Wang; Yanhua Yu

摘要：Objective To explore the predictive value of inflammatory factors and coagulation function for abdominal infec-tion in patients with liver cirrhosis and ascites. Methods A total of 82 patients with liver cirrhosis and ascites at Beijing You'an Hospital,Capital Medical University,from January to May 2024 were selected and divided into the infected group(n=37)and the uninfected group(n=45)according to the presence of abdominal infection.Inflammatory factors and coagulation function were compared between the two groups,and the correlations of inflammatory factors and coagulation function with abdominal infection were an-alyzed by Spearman's correlation.The factors influencing abdominal infection in patients with liver cirrhosis-associated ascites were identified by multivariate logistic regression.The predictive value of inflammatory factors and coagulation function for liver cirrhosis-associated ascites was evaluated by receiver operating characteristic(ROC)curve analysis. Results Among the 82 patients,there were 69 men and 12 women.The age range was 33-82 years,and the mean age was 59.2±11.5 years.There were 45 patients with abdominal infection(54.88%).Spearman's correlation analysis showed that abdominal infection was positively correlated with C-reactive protein(CRP),procalcitonin,international normalized ratio(INR),and D-dimer(DD).The multivariate logistic regression analysis showed that patients with higher CRP(odds ratio[OR]4.701,95%confidence interval[CI]1.040-21.253,P=0.044),higher procalcitonin(OR 4.800,95%CI 1.481-15.558,P=0.009),higher INR(OR 48.373,95%CI 1.088-64.462,P=0.041),and higher DD(OR 3.441,95%CI 1.045-11.327,P=0.042)were more likely to have abdominal infection.The area under the ROC curve(AUC)for CRP,PCT,INR,and DD for predicting abdominal infection in patients with liver cirrhosis-as-sociated ascites was 0.759(95%CI 0.655-0.863,P=0.000),0.756(95%CI 0.648-0.864,P=0.000),0.636(95%CI 0.513-0.757,P=0.036),and 0.659(95%CI 0.541-0.778,P=0.014),respectively,with sensitivity values of 0.8667,0.7778,0.7556,and 0.5111,respectively,and specificity values of 0.5405,0.7027,0.4865,and 0.8378,respectively. Conclusion Inflammatory factors and coagulation function have high predictive value for abdominal infection in patients with liver cirrhosis-associated ascites and may be important references for clinical treatment.