Association of dietary phytosterols with prevalence of metabolic dysfunction-associated fatty liver disease in adult population of Northeastern China:An internet-based cross-sectional study
Jiayu Zhu
Jiaqi Zhang
Qi Yu
Liyan Liu
Rennan Feng
Department of Nutrition and Food Hygiene,School of Public Health,Harbin Medical University,Harbin 150081,China;Key Laboratory of Precision Nutrition and Health of Ministry of Education,School of Public Health,Harbin Medical University,Harbin 150081,China
摘要：Objective:The benefits of phytosterols have attracted growing interest,but their association with Metabolic Dysfunction-Associated Fatty Liver Disease(MAFLD)has rarely been reported in population-based studies.This research aimed to investigate the correlation between dietary phytosterols and MAFLD.Methods:Phytosterols intake was evaluated using an internet-based dietary questionnaire targeted at the Chinese population.Conditional logistic regression models were employed to investigate dose-response relationships between phytosterol intake and MAFLD,as well as the potential preventive role of phytosterols.Restricted Cubic Spline(RCS)analyses were conducted to examine associations between phytosterols intake and MAFLD.Additionally,a quantile-based g-computation(qgcomp)method was applied to explore the combined effect of campesterol,stigmasterol,β-sitostelane,campestane,and β-sitosterol on MAFLD.Results:Significant inverse relationships were found between total phytosterols and MAFLD(OR,0.19;95%CI,0.11-0.32;P<0.001),campesterol(OR,0.22;95%CI,0.13-0.37;P<0.001),stigmasterol(OR,0.17;95%CI,0.10-0.30;P<0.001),β-sitostelane(OR,0.26;95%CI,0.16-0.45;P<0.001),campestane(OR,0.23;95%CI,0.14-0.39;P<0.001),and β-sitosterol(OR,0.17;95%CI,0.10-0.29;P<0.001).The qgcomp analysis showed a significant negative association between the five phytosterols and MAFLD(OR,0.58;95%CI,0.50-0.67;P<0.001).Additionally,the qgcomp analysis revealed that the combination of these five phytosterols was inversely associated with MAFLD,with stigmasterol contributing the most(weight=0.70).Conclusion:Higher intake of phytosterols was associated with a reduced prevalence of MAFLD,with stigmasterol showing the most significant inverse relationship.Further research is needed to clarify the relationship between phytosterols and MAFLD.
机标关键词：associationmetabolicpopulationstudyadultchinawithassociated
论文发表日期：2025-03-30
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：8( 50-57 )
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