Cold environments and health:proteomic analysis of health impacts
Hongquan Song1
Rui Zhang2
Zixin Lu3
Xiaohui Jiao1
Jiaqun Yan4
1.Department of Oral Maxillofacial Surgery,The First Affiliated Hospital of Harbin Medical University,Harbin 150001,China2.Department of Oral Maxillofacial Surgery,The First Affiliated Hospital of Harbin Medical University,Harbin 150001,China;Department of Stomatology,Nangang Branch,Heilongjiang Provincial Hospital,Harbin 150036,China3.School of Stomatology,Harbin Medical University,Harbin 150081,China4.Department of Stomatology,Harbin Medical University Cancer Hospital,Harbin 150081,China
摘要：Background:Cold temperatures cause blood vessels to constrict,shallow breathing,and slight thickening of the blood.Working in extremely cold environments can have negative effects on health,yet there are currently no effective biomarkers to monitor these health conditions.Proteins are important intermediate phenotypes that can provide a theoretical basis for understanding disease pathophysiology.Proteins in the circulatory system reflect the physiological status of individuals,and plasma proteins have significant potential as biomarkers for various health conditions.Methods:In this study,we employed the Mendelian randomization(MR)method to analyze the effects of freezing temperatures on over 2900 plasma proteins.Subsequently,the selected plasma proteins were subjected to causal analysis in relation to 55 diseases,including respiratory disorders,cardiovascular diseases,various cancers,and oral diseases.The aim was to identify proteins that could serve as biomarkers for health status.Results:Our results indicate that cold environments may affect the concentrations of 78 plasma proteins.Further MR analysis revealed that nine of these plasma proteins are associated with the risk of respiratory disorders,cardiovascular diseases,various cancers,and oral diseases.Conclusion:These proteins show promise as biomarkers for monitoring the hazards and risks faced by individuals working in cold environments.These findings provide valuable insights into the biological mechanisms underlying occupational hazards.
机标关键词：analysiscoldenvironmentshealthimpactsproteomic
论文发表日期：2025-03-30
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：7( 58-64 )
英文信息