Mediating function of heart failure in the causal relationship between diastolic blood pressure and hypertensive renal disease with renal failure:a mediated Mendelian randomization study
Lei Pang1
Zi-Jun Ding2
Hong-Qiang Chai3
Fei Li3
Ming Wu3
Wei-Bing Shuang4
1.Department of Urology,The Fifth Hospital of Shanxi Medical University(Shanxi Provincial People's Hospital),Taiyuan,Shanxi 030012,China;First Clinical Medical College of Shanxi Medical University,Taiyuan,Shanxi 030012,China2.Department of Neonatology,Shanxi Children's Hospital,Taiyuan,Shanxi 030013,China3.Department of Urology,The Fifth Hospital of Shanxi Medical University(Shanxi Provincial People's Hospital),Taiyuan,Shanxi 030012,China4.First Clinical Medical College of Shanxi Medical University,Taiyuan,Shanxi 030012,China;Department of Urology,The First Hospital of Shanxi Medical University,Taiyuan,Shanxi 030012,China
摘要：Objective:To study the causality relationship between diastolic blood pressure(DBP)and hypertensive renal disease with renal failure(HRDRF)and the mediating role of heart failure(HF)in the causality relationship by network Mendelian randomization(MR).
Methods:Genome-wide analysis of DBR HRDRF,and HF was downloaded from the public database(Genome-Wide Analysis Study[GWAS])and was used to analyze the results and to conduct mediated MR analysis.
Results:Analysis showedthat DBP was positively correlated with HRDRF(OR=1.0002,95％Cl:1.0001-1.0003,P=1.8076e-05)and DBP was positively correlated with HF(OR=1.0295,95％Cl:1.0221-1.0370,P=2.5292e-15).HF and HRDRF had a positive causal effect(OR=1.0001,95％CI:1.0000-1.0001,P=0.0152).Mediation analysis showed that the contribution ratio of HF to the combined effect of DBP and HRDRF was 24.69％.
Conclusions:DBP can increase the risk of renal disease with renal failure,and HF may play an important role in mediating this causal relationship.
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论文发表日期：2024-09-30
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：10( 285-294 )
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