The Role of Atrial Natriuretic Peptide (ANP) in Cardiopulmonary Diseases
Yiu-Fai CHEN
Ji An FENG
Tatsuhiko MORI
Gilbert J.PERRY
Suzanne Oparil
摘要：BSTRACT Atrial natriuretic peptide (ANP) is a peptide hormone that has potent natriuretic, diuretic,vasodilator, sympatholytic, and renin- and aldosterone- suppressing activities and is involved in the regulation of volume and electrolyte balance and blood pressure. Further, ANP has also been shown to inhibit cellular growth, proliferation and induce apoptosis in a variety of cell lines, including vascular smooth muscle cells and cardiac myocytes. Recent studies have demonstrated that ANP is not only involved in blood pressure and volume homeostasis but also in the direct regulation of cardiac growth. We and other investigators have demonstrated the existence of natriuretic peptide receptors in the heart and cardiac cells, suggesting that ANP has direct actions on cardiac tissue. Several recent in vivo studies have suggested that statement of ANP is inversely related to cardiac growth/hypertrophy. Transgenic mice overexpressing ANP have lower heart weight and blood pressure than wild type mice.
机标关键词：
分类号：R54(心脏、血管（循环系）疾病)
论文发表日期：2001-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：1( 83 )