Recent Research Advances in Ivabradine and Its Cardiovascular Effects
Zhao GAO
摘要：Elevated heart rate is a major risk factor for cardiovascular diseases. The inhibitor of funny current (Ⅰ (f)), a hyperpolarization-activated cyclic nucleotide-gated channel current, ivabradine is a new agent selectively reduc-ing heart rate devoid of other cardiovascular effects, which has come into the market in Europe for more than 3 years. It has been approved that pure heart rate reduction by ivabradine can improve myocardial ischemia, endothelial function and myocardial contractile function. Long-term administration will not increase all-cause mortality. Its therapeutic value in stable coronary artery disease has been verified in clinical practice, while in other fields of cardiovascular diseases still needs more evidence-based medical research. This article is a review about its recent research advances in experi-mental and clinical studies.
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分类号：R5(内科学)
论文发表日期：2009-04-02
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：6( 106-111 )
英文信息