Effects of valsartan on matrix metalloproteinase-2 and tissue inhibitor of matrix metalloproteinase-2 in atrial fibrillation patients
PEI Xiao-yang
PAN Ying
YAN Wen
HU Xue-song
摘要：To observe the effects of valsartan on matrix metalloproteinase-2(MMP-2)and tissue inhibitor of matrix metalloproteinase-2(TIMP-2)in atrial fibrillation patients.Methods 30 patients with non-vavular atrial fibrillation(NVAF)as atrial fibrillation group(AF group)were randomly divided into two groups:15 patients were in therapy group(valsartan 80 mg qd)and 15 patients were in control group.Plasma MMP-2 and TIMP-2 level between therapy and control group before and after treatment and 30 normal patients as normal group(SN group)were measured by ELISA.Results High levels of MMP-2 were observed in AF group comparing with normal group(P＜0.01),and the level of TIMP-2 was significantly lower(P＜0.01).There was no difference between therapy group and control group in MMP-2 and TIMP-2 before treatment.However,after three months treatment,MMP-2 in therapy group was significantly lower than control group(P＜0.001).While in therapy group there was a significant difference before and after in MMP-2(P＜0.01)and TIMP-2(P＜0.05).Conclusions There are high level of MMP-2 and lower TIMP2 in NVAF patients.Valsartan might inhibit the process of non-vavular atrial fibrillation by down regulating of MMP-2 and up regulating of TIMP-2.
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分类号：R5(内科学)
论文发表日期：2010-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
英文信息