Overcoming of insulin autoantibody mediated insulin resistance in a Chinese elderly patient with multi-organ dysfunction by withdrawal of insulin injection: a case report and review of literature
JIN Wen-sheng
XU Wei-guo
YIN Zhuo-na
XIE Zhi-quan
WANG Xiao-hui
ZHANG Ya-song
摘要：Insulin autoantibody(IAA)mediated insulin resistance(AMIR)is very rare in human insulin era.Here we report a typical case of a 90-year-old Chinese man who suffered from heart and renal dysfunction,lung infection and very poor blood glucose control,and meanwhile injected with higher than 200 U human insulin for his diabetes.His IAA was positive with high affinity to insulin,as insulin antigen-antibody binding rate was 52% in vitro.Serum insulin level and the binding rate decreased dramatically with cession of insulin injection; also blood glucose profile restored to response to previous dose insulin injection and remained during follow-up.Both the reason for the IAA formation and the solution to the AMIR were discussed in detail.
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分类号：R5(内科学)
论文发表日期：2010-04-02
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
英文信息