Correlation of carotid artery atherosclerosis with C-reactive protein and adiponectin in patient with metabolic syndrome

HAN Zeng-lei; ZHANG Yu-ying; CAO Qing-bo

摘要：Background Metabolic Syndrome(MS)is a group of conditions included hypertension,hyperlipidemia,central obesity,impaired glucose tolerance and insulin resistance,which may contribute to risk factors for atherosclerosis syndrome.Insulin resistance is the core mechanism? While the underlying mechanism is not clear.This article aims to study the correlation of carotid atheroselerosis with C-reactive protein and adiponectin in metabolic syndrome(MS)patients.Methods According to bilateral carotid artery atherosclerosis echocardiography,226 patients with metabolic syndrome were randomized to three groups,of which were non-carotid atherosclerosis plaque group(MS-1 group,n =94),carotid artery atherosclerosis plaque group(MS-2 group,n = 132),and normal control group(n = 36).Determination of serum insulin,high sensitivity C-reactive protein,adiponectin and bilateral carotid artery atherosclerosis ultrasonography and other indicators,semi-quantitative estimates of the extent and severity of plaque.Results ①In two MS groups,carotid artery atherosclerosis,intima-media thickness(IMT),insulin resistance index(HOMA-IR)and high sensitive C-reactive protein(hs-CRP)were significantly higher than the control group(P < 0.01),while adiponectin was lower than the control group(P < 0.01); When MS-2 group was compared to MS-1 group,there were significant differences(P < 0.01).②IMT was positively correlated with HOMA-IR and hs-CRP(P < 0.01)while negatively correlated with adiponectin(P < 0.01).Conclusions C-reactive protein and adiponectin in MS patients were correlated with carotid atherosclerosis and insulin resistance,which may be used as the assessment of MS patients.