Myocardium reperfusion injury

MO Zhi-ming; SU Li

摘要：The phenomenon of ischemia/reperfusion injury is described in the experimental models of acute myocar-dial infarction (AMI), causing additional functional and structural damage to the acute reperfused myocardium, andischemic preconditioning refers to the myocardial ischemia after a long period of reperfusion before one or several short-occasional duplication of myocardial ischemia/reperfusion1, which can increase myocardial ischemic tolerance. Thetherapeutic strategies for AMI have focused on myocardial ischemia/reperfusion injury, which accounts for a significantpart of the final infarct size. Although experiments in the last 20 years have reported that pharmacological interventionsat reperfusion might reduce myocardial reperfusion injury, this could not be confirmed in human studies. An alternativeto chemical modifiers, postconditioning (brief repeated periods of ischemia applied at the onset of reperfusion) is an-other method proven to be efficient in animal models and to be confirmed in recent human studies. This simplemethod, applied in the first minute of repedusion, reduces the final infarct size by 30% - 50%. This review will focuson the mechanisms, pharmacological preconditioning, postconditioning technique, which is easily applicable in humanpatients in the setting of AMI.