Early monitoring of pro-brain natriuretic peptide and its diagnostic value in burn victims
HUANG Zhi-feng
CHEN Hua-de
ZHENG Shao-yi
摘要：Background Myocardial impairment is often precipitated after bum.Previously,cardiac enzyme profile was often measured to determine myocardial injury,but was hardly specific.In this study,we investigated early changes of plasma N-terminal pro-brain natriuretic peptide(NT-proBNP)over time and its diagnostic value in bum patients.Methods 131 patients with heat burn were assigned to mild group(n = 19),moderate group(n = 31),severe group(n = 35)and extremely severe group(n = 35)based on their conditions.NT-proBNP and troponin Ⅰ(cTnⅠ)were continuously measured on days 1,3,5 and 7,respectively after admission.Results Significant differences were found on day 3,5 and 7 between moderate bum group and mild bum group(P < 0.05); increase appeared earlier and lasted longer in severe group and extremely severe group as compared to mild and moderate groups(P < 0.05).Conclusions NT-proBNP is related to the severity of bum and can well reflect the status of myocardial injury in patients with severe bum,making it an ideal marker for myocardial injury in bum patients.
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分类号：R5(内科学)
论文发表日期：2010-10-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
英文信息