Impact of intensive statin therapy on hs-CRP and sCD40L in AMI patients during perioperative period of emergency PCI

Cao Qing-bo; Wang Xiu-wei; Han Zeng-Iei; Sun Xue-yu

摘要：Background It's an effective treatment to achieve percutaneous coronary intervention (PCI) in acute myocardial infarction (AMI) patients for reperfusion of coronary artery. The PCI treatment can improve the blood supply of coronary artery, make some adverse effects at the same time. Studies have shown that statins have other effects in addition to lipid-lowering, such as anti-inflammatory effects. It can significantly reduce the incidence of coronary heart disease, cardiovascular disease mortality and even all-cause mortality. The aim of this study was to investigate the clinical effects and significance of intensive atorvastatin in AMI patients during perioperative period of PCI. Metbods One hundred twelve AMI patients were randomly divided into three groups. The control group (n = 32) was given the routine medicine, and the two therapy groups were administered atorvastatin 80 mg or 40 mg before PCl,and then were administered atorvastati 40 mg q.d or 20 mg q.d after PCL. Levels of high-sensitive C-reactive protein (hs-CRP), sCD40L, myocardial enzymes and lipid was determined and compared after PCI. Results Compared with the control group, the levels of serum hs-CRP, CD40L in treatment group 1 (n, = 40) and treatment 2 group (n, = 40) were sigruficantly decreased (P < 0.05), and there was significant difference between two treatment groups (P < 0.01). Conclusion Intensive treatment of atorvastatin in AMI patients during PCI perioperative period is beneficial, possibly through Mechanisms such as anti-inflammatory, anti-platelets, and stability of plaque and coronary vascular endothelial function.