Impact of prolonged dual antiplatelet therapy on patients after drug-eluting stents implantation
HE Peng-cheng
TAN Ning
YANG Da-hao
CHEN Ji-yan
LUO Jian-fang
ZHOU Ying-ling
摘要：Background Impact of dual antiplatelet therapy beyond 12 months on patients implanted with DES remains unsolved.Methods From January 2010 to June 2011,1873 patients who have been taking DAPT and free from death,myocardial infarction,stroke,repeat coronary revascularization,stent thrombosis,and major or minor bleeding according to TIMI criteria for 12 months after implantation of DES were randomly assigned to continuous (prolonged DAPT group) or discontinuous (standard DAPT group) clopidogrel (75 mg/day).The primary outcome was major adverse cardiovascular events (MACEs) which compose of death,nonfatal myocardial infarction (MI),nonfatal stroke,target vessel revascularization (TVR) or stent thrombosis (ST) at 180 days.Results There was no significant difference in the incidence of 180-day MACEs between prolonged DAPT group and standard DAPT group (8.98 ％ versus 10.13 ％,respectively,P =0.400).The frequency of major bleeding was 0.64 ％ in prolonged DAPT arm and 0.43％ in standard DAPT arm (P =0.523), that of minor bleeding was 3.32 ％ versus 2.87 ％ (P =0.585),respectively.Conclusions Prolonged DAPT beyond 12 months neither improve prognosis nor increase risk of bleeding in patients implanted with DES.
机标关键词：
分类号：R541.4(心脏、血管（循环系）疾病)
论文发表日期：2012-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
英文信息