Association of klotho protein with contrast-induced nephropathy in patients with ST elevation myocardial infarction undergoing percutaneous coronary intervention
WANG Yu
CHEN Xiao-lan
KE Zu-hui
HUANG Si-hui
YU Dan-qing
摘要：Background Serum Klotho protein level is a novel marker for various types of renal injury.However,the association of Klotho protein with contrast-induced nephropathy (CIN) in patients with ST elevation myocardial infarction (STEMI) with percutaneous coronary intervention (PCI) is unclear.Methods According to predefined criteria,143 STEMI patients undergoing PCI were included in this analysis.Clinical data were compared and multivariate logistic regression analysis was performed to detect the risk factors of CIN.Results 24 patients were diagnosed with CIN (16.8％).Serum Klotho protein level was significant lower in the CIN group (0.35±0.16 vs.0.47±0.18,P =0.004).Multivariate logistic regression analysis showed that serum Klotho protein was independently associated with decreased risk of CIN (OR =0.03,95％ CI:0.00-0.57,P =0.019).Conclusions Serum Klotho protein may be a useful marker for diagnosis of CIN in patients with STEMI undergoing PCI.
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论文发表日期：2018-09-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：5( 157-161 )
英文信息