Association of circadian blood pressure pattern and left heart chamber enlargement in hypertensive patients:A cross-sectional study
ZHONG Qi
CAI An-ping
LIU Chao-fan
ZHOU Dan
LI Xi-da
FENG Ying-qing
ZHOU Ying-ling
1.Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of Coronary Disease, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China2.Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of Coronary Disease, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China3.Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of Coronary Disease, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China4.Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of Coronary Disease, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China5.Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of Coronary Disease, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China6.Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of Coronary Disease, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China7.Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of Coronary Disease, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China
摘要：Background Non-dipping blood pressure(BP)pattern is a potential risk factor contributing to cardiac geom-etry change.Relationship between BP pattern and left atrium(LA)enlargement besides left ventricle(LV)struc-tural change is seldom studied.Methods A total of 237 hypertensive and hospitalized adults were enrolled.Left heart chamber parameters were measured by 2-dimensional echocardiography,and BP circadian rhythm was eval-uated by 24-hour ambulatory blood pressure monitoring.Night-day ratios of systolic BP(NDR-SBP)were calcu-lated and BP patterns were classified into dippers,reduced-dippers,and risers,which were defined as NDR-SBP ＜0.9,≥0.9 and ＜1,≥1,respectively.Multiple logistic regression analyses were performed to identify the factors as-sociated with increased left ventricular end-diastolic internal diameter and left atrial diameter.Results Among enrolled participants,there were 62(26.2％)dippers,136(57.4％)reduced-dippers and 39(16.5％)risers.Briefly,57.8％were male and the mean age was 57.0±13.9 years.Compared to the dippers,both left ventricular end-dia-stolic diameter(44.4±4.3 mm in dippers,45.5±4.0 mm in reduced-dippers,46.5+4.5 mm in risers,P=0.045)and left atrial diameter(32.7±4.1 mm in dippers,34.3±4.7 mm in reduced-dippers,35.7+4.3 mm in risers,P=0.004)were progressively increased in reduced-dippers and risers.Logistic regression analyses showed that after adjust-ed for age,male gender,history of diabetes,blood lipid profiles,mean diurnal BP and estimated glomerular filtra-tion rate,the association between increased LV diameter and riser BP pattern was significant(OR:2.621,95％CI:1.030-6.678)while the association between increased LA diameter and riser BP pattern was marginally signif-icant.Conclusions The riser BP pattern is associated with the enlargement of LV and probably that of LA in hy-pertensive patients independent of 24-hour systolic BP level.
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论文发表日期：2020-12-30
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：8( 227-234 )
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