Long non-coding RNAs in cardiac fibrosis:Regulation of cardiac fibroblasts
HUANG Si-hui1
CHEN Guo2
HE Xu-yu2
YU Dan-qing2
1.Department of Cardiology, Guangdong Cardiovascular Insti-tute, Guangdong Provincial Key Laboratory of Coronary Heart Dis-ease Prevention, Guangdong Provincial People' s Hospital, Guang-dong Academy of Medical Sciences, Guangzhou 510080, China;The Second School of Clinical Medicine, Southern Medical Universi-ty, Guangzhou 510515, China2.Department of Cardiology, Guangdong Cardiovascular Insti-tute, Guangdong Provincial Key Laboratory of Coronary Heart Dis-ease Prevention, Guangdong Provincial People' s Hospital, Guang-dong Academy of Medical Sciences, Guangzhou 510080, China
摘要：Background Cardiac fibrosis,characterized by excessive extracellular matrix(ECM)deposi-tion and increased cardiac fibroblasts(CFs)activity,is a common pathology of various cardiovascu-lar diseases.Cardiac fibrosis decreases ventricular compliance,increases diastolic filling pressure,decreases cardiac oxygen supply,and ultimately impairs the cardiac output.CFs are the main effect-er cell type in regulating ECM and predominantly drive the fibrosis process.Despite the critical im-portance of CFs,our limited understanding of CFs impedes the development of potential therapies that effectively target this cell type and its pathological contribution to disease progression.Recent-ly,long non-coding RNAs(lncRNAs)are emerging as important pathological and physiological regulators of cardiac fibrosis,shedding light on novel molecular mechanisms and potential thera-peutic targets.This review discussed the current knowledge regarding the lncRNAs involved in car-diac fibrosis and summarized their possible molecular mechanisms with special focus on the regula-tion of CFs.
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论文发表日期：2020-12-30
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：12( 292-303 )
英文信息