The prognostic value of liver function assessment tools in patients with ST-segment elevation myocardial infarction
ZHANG Kai-jun1
WANG Zhong-hua2
LIAO Xiao-long2
GUO Wei-xin2
1.Department of Geriatric Gastroenterology,Guang-dong Provincial Geriatrics Institute,Guangdong Provincial People's Hospital,Guangdong Academy of Medical Sciences,Guangzhou 510080,China2.Department of Geriatric Inten-sive Medicine,Guangdong Provincial Geriatrics Institute,Guangdong Provincial People's Hospital,Guangdong Acade-my of Medical Sciences,Guangzhou 510080,China
摘要：Background Liver dysfunction was associated with poor outcomes in patients with ST-segment elevation myocardial infarction (STEMI).However,the optimal methods for assessing the liver function was unclear.This study was to compare the predictive value of the different liver function assessment tools for in-hospital and one-year adverse events in STEMI patients undergoing percutaneous coronary intervention (PCI).Methods A total of 1157 patients with STEMI undergoing PCI were enrolled from January 2012 to December 2015.The model for end-stage liver disease excluding international normalized ratio (MELD-XI) and albumin-bilirubin (ALBI)score were calculated at admission.The discrimination and calibration of these two scores for in-hospital and one-year adverse events were compared.Results The in-hospital mortality was 4.0％.Both MELD-XI[area under the curve (AUC) =0.768,95％ confidence interval (CI):0.691-0.845,P＜0.001]and ALBI score (AUC =0.682,95％ CI:0.602-0.761,P＜0.001) had excellent discrimination for in-hospital death.The calibration for in-hospital death was good in MELD-XI (Hosmer-Lemeshow chi-square =7.2,P=0.520),but not good in ALBI score (Hos-mer-Lemeshow chi-square =13.8,P=0.087).In addition,the predictive power of MELD-XI for in-hospital death was better than ALBI score (AUC:0.768 vs.0.682,P=0.037).1108 (95.8％) patients completed one-year follow-up.Kaplan-Meier analysis showed that patients with a high MELD-XI score had high-risk of one-year mortality(Log-rank test:54.8,P＜0.001).Conclusions As the method for assessing the liver function,MELD-XI was bet-ter than ALBI score in predicting the in-hospital and one-year adverse events in STEMI patients,which could be considered as a risk assessment tool.
机标关键词：
论文发表日期：2021-09-30
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：5( 177-181 )
英文信息