Research progress on the correlation between cathepsin L and cardiovascular disease
BI Tian-tian1
YAN Bo2
1.Jining Medical University,Jining 272067,Shan-dong,China2.The Center for Molecular Genetics of Cardio-vascular Diseases,Affiliated Hospital of Jining Medical Uni-versity,Jining Medical University,Jining 272067,Shandong,China;Shandong Provincial Sino-US Cooperation Research Center for Translational Medicine,Affiliated Hospital of Jin-ing Medical University,Jining Medical University,Jining 272067,Shandong,China;Shandong Provincial Key Labora-tory of Cardiac Disease Diagnosis and Treatment,Affiliated Hospital of Jining Medical University,Jining Medical Univer-sity,Jining 272067,Shandong,China
摘要：Background Cathepsin L (CTSL),a member of the cysteine protease cathepsin family,is an important Lyso-somal peptidase,which has the best activity in an acidic environment and less activity in a neutral environment.Its physiological function involves proteolysis,antigen presentation,T cell development,cell apoptosis,and em-bryonic development,and is closely related to the occurrence and development of various types of cancer,cardio-vascular disease,and kidney disease.In this paper,the role and mechanism of CTSL in the development of athero-sclerosis,coronary heart disease,restenosis,abdominal aortic aneurysm,and dilated cardiomyopathy were briefly reviewed.
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论文发表日期：2021-09-30
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：6( 210-214,封3 )
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