Research progress on the correlation between S100 protein family and Kawasaki disease with coronary artery aneurysm
PAN Yan1
LV Peng-fei2
FAN Qi-hong1
LU Hong-zhu1
1.Department of Pediatrics,the First Affiliated Hospi-tal of Yangtze University,Jingzhou,434000,Hubei Province,China2.Jingzhou Institute of Technology,Jingzhou 434000,Hubei Province,China
摘要：Background Kawasaki disease(KD)is the systemic vasculitis with unknown cause.The S100 protein out-side cells have an important effect on congenital and adaptive immunity,chemotaxis,white blood cell(WBC)and tumor cell invasion,tissue growth and repair.Recently,multiple works have investigated the value of S100 pro-teins as the predictive biomarker of KD.The most serious complication of KD is coronary artery aneurysm(CAA).KD is the most common cause of acquired heart disease among children within developed countries and a risk factor for myocardial infarction in early adulthood.Early treatment with intravenous immunoglobulin(IVIG)has been shown to reduce the risk of CAA in KD from 15％-25％to about 4％.S100 family proteins are calcium-binding proteins,some of which have been shown to have intracellular and extracellular functions associ-ated with inflammation.Persistent elevation of S100 protein level(S100A8/A9 and S100A12)after IVIG therapy was reported in patients suffering CAA.In this paper,the role and mechanism of S100 protein family in CAA de-velopment in patients with KD were briefly reviewed.
机标关键词：correlationresearchproteinbetweenfamilywithaneurysmartery
论文发表日期：2022-03-30
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：6( 1-6 )
英文信息