The role of cellular senescence in cardiac development,regeneration and diseases
YAN Lei1
LIU Nan-bo2
ZHU Shuo-ji2
ZHU Ping2
ZHANG Hui1
1.School of Life Science and Technology,Shanghai-Tech University,Shanghai 201210,China2.Guangdong Car-diovascular Institute,Guangdong Provincial People's Hospital,Guangdong Academy of Medical Sciences,Guangzhou,Guang-dong 510100,China;Guangdong Provincial Key Laboratory of Pathogenesis,Targeted Prevention and Treatment of Heart Disease
摘要：Background Cellular senescence,an irreversible state of cell-cycle arrest triggered by multiple stress factors,plays a key role in organ development and wound healing.Accumulated senescent cells also promote tissue inflam-mation and involve in various diseases including myocardial infarction,atherosclerosis,diabetes and nonalcoholic steatohepatitis.Understanding the mechanism and consequences of cellular senescence is crucial to develop new therapies for diseases.Here,we describe the characteristics of senescent cells and involvement of senescent cardiac cells in heart development,regeneration and diseases.We summarize the work in this area and provide directions and clues for future studies.
机标关键词：developmentregenerationsenescencecellularrolecardiacdiseases
论文发表日期：2022-03-30
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：9( 19-26,32 )
英文信息