The association between SNPs of folate metabolism genes and congenital heart diseases:A systematic review and sequential meta-analysis
SHU Jing1
YE Zi-wei1
WANG Ting-ting2
CHEN Le-tao1
ZHANG Sen-mao1
ZHU Ping3
QIN Jia-bi2
1.Department of Epidemiology and Health Statistics,Xiangya School of Public Health,Central South University,110 Xiangya Road,Changsha 410078,Hunan,China2.Department of Epidemiology and Health Statistics,Xiangya School of Public Health,Central South University,110 Xiangya Road,Changsha 410078,Hunan,China;NHC Key Laboratory of Birth Defect for Research and Prevention(Hunan Provincial Ma-ternal and Child Health Care Hospital),Huangjiang Avenue,Changsha 410100,Hunan,China3.Cardiovascular Institute,Guangdong Provincial People's Hospital,Guangdong Academy of Medical Sciences,106 Zhongshan Er Road,Guangzhou 510100,Guangdong,China
摘要：Background Aims:To summarize the epidemiologic evidence on the association between single nucleotide polymorphisms(SNPs)of folate metabolism genes from parents and children and risk of congenital heart diseases(CHDs)by a comprehensive systematic review and meta-analysis.Methods and results:PubMed,Embase,Google Scholar,Cochrane Libraries,and Chinese databases were searched to identify potential studies through July 2021 For mothers,the polymorphisms of Methylenetetrahydrofolate Reductase(MTHFR)at rs1801133 and rs1801131 were significantly associated with risk of CHDs in the homozygote comparisons(T/T vs C/C at rs1801133:OR:1.50,95％CI:1.31-1.71;C/C vs A/Aatrs1801131:OR:1.39,95％CI:1.04-1.86).For fathers,the polymorphisms of MTHFR at rs 1801133 were significantly associated with risk of CHDs in the heterozygote com-parisons(C/T vs C/C∶OR∶1.26,95％CI∶1.04-1.53).For children,the polymorphisms of MTHFR at rs1801133(T/T vs C/C∶OR∶2.05,95％CI∶1.57-2.66),rs1801131(A/C vs A/A∶OR∶1.32,95％CI∶1.06-1.63),andrs2274976(G/A vs G/G∶OR∶0.75,95％CI∶0.61-0.92),and methionine synthase reductase(MSR)at rs 1801394(G/G vs A/A∶OR∶1.85,95％CI∶1.21-2.85)and rs1532268(T/T vs C/C∶OR∶2.44,95％CI∶1.15-5.21;C/T vs C/C∶OR∶1.53,95％CI∶1.11-2.10).This review also assessed the risk of specific CHD subtypes associated with folate metabolism gene SNPs of children.Relevant heterogeneity moderators have been identified by subgroup analysis.Sensitivity analy-sis yielded consistent results.No evidence of publication bias was observed.Conclusions:The present study indi-cates that polymorphisms of maternal MTHFR at rs 1801133 andrs1801131,parental MTHFR at rs 1801133,as well as children's MTHFR at rs1801133,rs1801131 and rs2274976,and MSR at rs1801394 and rs1532268 are signifi-cantly associated with risk of CHDs.
机标关键词：meta-analysisassociationbetweensnpsreviewheartgenescongenital
论文发表日期：2022-03-30
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：35( 60-94 )
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