Impact of Malnutrition on Contrast-associated Acute Kidney Injury and follow-up mortality in Patients undergoing Coronary Angiography
Yihang Ling1
He Yi-bo2
Yu Si-jia1
Liu Yong2
Chen Ji-yan1
1.The Second School of Clinical Medicine,Southern Medical University,Guangzhou,510515,China;Department of Cardi-ology,Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention,Guangdong Cardiovascular Institute,Guang-dong Provincial People's Hospital,Guangdong Academy of Medical Sciences,Guangzhou 510080,China2.Department of Cardi-ology,Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention,Guangdong Cardiovascular Institute,Guang-dong Provincial People's Hospital,Guangdong Academy of Medical Sciences,Guangzhou 510080,China
摘要：Background Malnutrition is prevalent in patients with coronary disease.However,it's unknown whether malnutrition would affect the risk of CA-AKI in patients undergoing coronary angiography(CAG).Methods We included patients with documented data for calculating controlling nutritional status(CONUT)score from a prospective multicenter cohort study(REICIN study)recruiting 4271 consecutive patients undergoing CAG(with or without percutaneous coronary intervention)from January 2013 to February 2016(NCT01402232).Patients were stratified as normal group(CONUT score 0-1),mild malnutrition group(CONUT score 2-4)and severe malnutrition group(CONUT score＞4).CA-AKI was defined as an increase of serum creatinine level of＞0.3 mg/dL or＞50％within the first 48 hours since the procedure.The association of malnutrition and the risk of CA-AKI was examined by multivariable logistics regression analysis.3862 patients undergoing CAG(median age:63.1±10.7 years,76.7％were male)were finally included in this study.Results Overall,1769(45.8％)patients were complicated with mild malnutrition,386(10.0％)were with severe malnutrition and 127(3.3％)patients eventually developed CA-AKI.The patients in severe malnutrition status were older,with worse cardiorenal function and had higher CA-AKI incidence than those without malnutrition.Adjusted multivariate logistic regression analysis dem-onstrated that mild malnutrition was 1.76-fold(95％CI 1.07-2.95)and the severe malnutrition was 2.77-fold(95％CI 1.41-5.37)higher risk of CA-AKI(all P＜0.05,respectively)compared with patients in normal nutrition status.In addition,malnutrition level was also associated with an elevated risk of follow-up all-cause mortality(Log-Rank P＜0.001).Conclusion Malnutrition is prevalent and associated with increased risk of CA-AKI among patients undergoing CAG.
机标关键词：angiographycontrastkidneyimpactacuteassociatedcoronaryfollow-up
论文发表日期：2022-12-30
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：9( 254-262 )
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