Early use of mTOR inhibitors-based immunosuppression in heart transplantation recipients:a systematic review and meta-analysis of randomized controlled trials
LIN Jian-xin
JIANG Yan-zhi
WANG Yu-hong
TIAN Run-ze
ZHENG Rui
GUO Yan-ping
ZHU Ping
Guangdong Cardiovascular Institute,Guangdong Provincial People's Hospital,Guangdong Academy of Medical Sciences,Guangzhou,Guangdong 510100,China;Guangdong Provincial Key Laboratory of Pathogenesis,Targeted Prevention and Treatment of Heart Disease,Guangzhou Key Laboratory of Cardiac Pathogenesis and Prevention
摘要：The aim of our study is to assess the efficacy and safety of early use of mTOR inhibitors-based immu-nosuppression compared with standard immunosuppression in heart transplantation recipients.We reviewed eight randomized controlled trials identified from Medline/PubMed,Embase,web of science,Transplant Library and Cochrane Library to evaluate the effects of mTOR inhibitors therapy on outcomes of biopsy-proven acute rejection,acute rejection associated with hemodynamic compromise,death,cytomegalovirus infection,post-transplant malig-nancy,cardiac allograft vasculopathy,maximal intimal thickness and renal function.Meta-analysis including 2066 recipients showed a significantly lower incidence of biopsy-proven acute rejection,cytomegalovirus infection,car-diac allograft vasculopathy and decreased maximal intimal thickness change.In conclusion,our meta-analysis sug-gested that early use of mTOR inhibitors-based immunosuppression were more effective and safer compared with standard immunosuppression in heart transplant recipients,especially in reducing acute rejection,cytomegalovirus infection,cardiacallograft vasculopathy and preserving renal function when combined with reduced calcineurin inhibitors.
机标关键词：meta-analysisinhibitorsreviewmtorheartbasedcontrolledearly
论文发表日期：2022-12-30
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：11( 279-289 )
英文信息