Animal models for the study of atherosclerosis:Current status and questions
YANG Xia-wen1
TAN Xuan2
WANG Chuan3
FAN Jiang-lin4
ZHU Ping1
1.Guangdong Cardiovascular Institute,Guangdong Pro-vincial People's Hospital(Guangdong Academy of Medical Sci-ences),Southern Medical University,Guangzhou 510100,Chi-na2.Department of Obstetrics and Gynecology,The First Affili-ated Hospital of Jinan University,Guangzhou 510630,China3.Department of Pharmacology,Shaanxi University of Chinese Medicine,Xianyang 712000,China4.Department of Molecular Pathology,Interdisciplinary Graduate School of Medicine and Engineering,University of Yamanashi,Chuo 409-3898,Japan
摘要：Experimental animal model is an essential tool in the study of lipid metabolism disorders and athero-sclerosis.Since the first use of rabbits fed a high-fat diet by Russian researchers in the last century,a variety of ani-mal models have been used to study atherosclerosis.Currently,engineered mice arethe most common animal mod-els.However,either in the basic study to elucidate the mechanisms,orin the clinical bridging study to develop new diagnostic and therapeutic methods for atherosclerosis,there are still many challenges:Which animal model should be selected?And how to interpret the results obtained from the selected animal model?Notably,human atheroscle-rosis is a disease that develops over time through a complex interaction of genetic and environmental factors,finally leading to complications such as myocardial infarction and stroke.Unfortunately,many results of atherosclerosis studies cannot be applied to humans,due to the current experimental animal models cannot mimic the complex le-sions and complications in humans.In this review,we would like to discuss the current status and future challenges of experimental animal models for the study of lipid metabolism disorders and atherosclerosis.
机标关键词：currentmodelsstudyanimalatherosclerosisquestionsstatus
论文发表日期：2023-12-30
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：6( 208-213 )
英文信息