Systemic immune-inflammation index:A predictor of ma-jor adverse cardiovascular events for patients with acute coronary syndrome
QU Wei1
JIANG Ting-ting2
AN Zi-qiang1
XU Hai-jia1
1.Limin Hospital of Weihai High Distric,Weihai City 264400,Shandong Province,China2.Songcun Health Center,Wendeng District,Weihai City 264400,Shandong Province,China
摘要：Background Systemic immune-inflammation index(SII)has emerged as a potential marker for assessing in-flammation and predicting outcomes in patients with acute coronary syndrome(ACS).However,its role in forecast-ing clinical prognosis in ACS patients undergoing primary coronary angiography remains unclear.Methods This retrospective study included 657 ACS patients who underwent primary coronary angiography between January 2016 and January 2023.Patients were divided into low and high SII groups based on the Youden index cut-off val-ue.The primary endpoint was the occurrence of major adverse cardiovascular events(MACEs),including nonfatal myocardial infarction(MI),nonfatal stroke,heart failure,target lesion revascularization(TLR),and cardiovascular death.Kaplan-Meier survival analysis and Cox regression were performed to assess the association between SII and outcomes.Results Patients with high SII had significantly higher rates of MACEs(25.7％vs.10.3％,P＜0.001),including nonfatal MI,heart failure,and TLR.After adjusting for conventional risk factors,SII remained an inde-pendent predictor of MACEs(HR:2.102,95％CI:1.616-3.011,P=0.002).Kaplan-Meier analysis confirmed poorer event-free survival in the high SII group(P=0.00093).Conclusions Elevated SII was associated with a higher risk of adverse outcomes in ACS patients,suggesting its potential utility as a comprehensive tool for risk stratifica-tion and prognosis in ACS patients.[S Chin J Cardiol 2024;25(3):142-148]
机标关键词：indexwithacuteadversecardiovascularcoronaryeventsimmune
论文发表日期：2024-09-30
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：8( 142-148,155 )
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