Efficacy and safety of 10 mg/d vs.20 mg/d rosuvastatin in elderly patients with coronary heart disease and hyperlip-idemia

CHEN Hui-qin

摘要：Background Population aging has become a common concern in the world.coronary heart disease(CHD)is one of the major diseases that lead to the death of the elderly and affect the quality of life.Studies have confirmed that increase in blood lipids is an independent risk factor for the occurrence and development of coronary heart disease.Therefore,adjusting the level of blood lipids effectively has significant value to allevi-ate the severity,slow the progression and reduce the occurrence of complications of coronary heart disease.Statins can play a role in regulating the blood lipids.Although rosuvastatin is a kind of highly potent statin that is often used at present,the effects of different doses of rosuvastatin on elderly patients with coronary heart disease and hyperlipidemia were seldom reported.Methods In this study,60 elderly patients with coro-nary heart disease and hyperlipidemia admitted to our hospital from 2021 to July to September 2023 were ret-rospectively selected.30 patients with 10 mg/d rosuvastatin were assigned to the control group and 30 patients with 20 mg/d rosuvastatin were assigned to the observation group,and their efficacy and safety were com-pared and analyzed.Results The total effective rate of observation group was 96.67％,which was higher than that of control group 86.67％(P＜0.05).Before treatment,there was no significant difference in blood lip-id levels between the two groups(P＞0.05).After treatment,the levels of total cholesterol(TC),triglyceride(TG),low density lipoprotein(LDL-C)and high density lipoprotein(HDL-C)were lower in the observation group(P＜0.05).And there was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusions The effect of 20 mg/d of rosuvastatin in the treatment of elderly CHD pa-tients with hyperlipidemia is better than that of 10 mg/d of rosuvastatin,which can effectively regulate the lev-el of blood lipids in the body without causing excessive adverse reactions.[S Chin J Cardiol 2024;25(3):149-155]