Research progress on gene polymorphisms related to the renin-angiotensin-aldosterone system and essential hypertension
WEI Jing-lian
DONG Tian-wei
YANG Guang-yuan
WANG Wang
RUAN Ming-yang
NIU Tie-zheng
Department of Cardiology,The First Affiliated Hospital of Jiamusi University,Jiamusi Heilongjiang 154000,China
摘要：Background Essential hypertension(EH)is a complex polygenic genetic disease,which is the result of the in-teraction of multiple genetic factors,environmental factors,and risk factors.The susceptibility of inherited genes is an important risk factor for EH,and pathogenic genes and susceptibility loci can promote EH formation.It has been found that renin-angiotensin angiotensin aldosterone system(RAAS)genes are involved in most physiological reg-ulation in humans,especially with EH.Its gene polymorphisms and EH susceptibility are current research hotspots.Therefore,this article reviewed the research on the correlation between angiotensinogen(AGT),angiotensin-con-verting enzyme(ACE),angiotensin Ⅱ.receptor type 1(AGTR1),aldosterone synthetase(CYP11B2),and beta 1-ad-renergic receptor(ADRB1)gene with EH,respectively.[S Chin J Cardiol 2024;25(3):193-199]
机标关键词：hypertensionaldosteroneresearchsystemgeneangiotensinessentialpolymorphisms
论文发表日期：2024-09-30
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：7( 193-199 )
英文信息