Triglyceride-glucose index is associated with in-hospital pulmonary infection and bleeding in patients with ST-seg-ment elevation myocardial infarction undergoing percuta-neous coronary intervention
ZENG Lin1
JIN Wei-zhen2
ZHEN Ci-en3
YANG Man4
LI Yu4
PENG Shi-min4
XIE Li-xin5
DUAN Chong-yang6
LIU Yuan-hui7
SUN Zhong-chan4
ZHUANG Yan2
HE Peng-cheng1
1.Department of Cardiology,Guangdong Cardiovascular Institute,Guangdong Provincial People's Hospital,Guangdong Acad-emy of Medical Sciences,Guangzhou 510080,China;Department of Cardiology,Guangdong Provincial People's Hospital(Guang-dong Academy of Medical Sciences),Southern Medical University,Guangzhou 510080,China2.Department of Biostatistics,School of Public Health,Southern Medical University,Guangzhou 510515,China3.Department of Cardiology,Guangdong Provincial People's Hospital(Guang-dong Academy of Medical Sciences),Southern Medical University,Guangzhou 510080,China;Department of Cardiology,School of Medicine,South China University of Technology,Guangzhou 510006,China4.Department of Cardiology,Guangdong Provincial People's Hospital(Guang-dong Academy of Medical Sciences),Southern Medical University,Guangzhou 510080,China5.Department of Cardiology,Shangyou People's Hospital,Ganzhou 341200,China6.State Key Laboratory of Organ Failure Research,Department of Biostatistics,School of Public Health,Southern Medical University,Guangzhou 510515,China7.Department of Cardiology,Guangdong Provincial People's Hospital(Guang-dong Academy of Medical Sciences),Southern Medical University,Guangzhou 510080,China;Department of Cardiology,Guangdong Cardiovascular Institute,Guangdong Provincial People's Hospital,Guangdong Acad-emy of Medical Sciences,Guangzhou 510080,China
摘要：Background The triglyceride-glucose(TyG)index has been widely studied in metabolic and cardiovascular diseases.ST-segment elevation myocardial infarction(STEMI)patients undergoing percutaneous coronary inter-vention(PCI)are at increased risk of pulmonary infection due to their stressful conditions.While previous studies have confirmed the predictive role of TyG index in the prognosis of STEMI patients,its potential association with pulmonary infection remains unclear.This study was to explored the relationship between the TyG index and pul-monary infection in STEMI patients PCI.Methods STEMI patients who underwent PCI were enrolled and strati-fied into three tertiles based on the TyG index measured after receiving PCI.Primary outcome was pulmonary infec-tion during hospitalization.Secondary outcomes were in-hospital bleeding,all-cause mortality and major adverse cardiac events(MACE)as well as MACE during follow-up.Logistic regression and Cox proportional hazard re-gression were mainly used to estimate outcomes.Results 3652 patients were enrolled in this study.In multivari-ate logistic regression,the TyG index was associated with in-hospital pulmonary infection[adjusted odds ratio(aOR):1.29,95%CI:1.05-1.58,P=0.014],mortality(aOR:2.27,95%CI:1.64-3.15,P<0.001),MACE(aOR:1.81,95%CI:1.39-2.37,P<0.001),and any bleeding(aOR:1.22,95%CI:1.04-1.43,P=0.013).The median follow-up was 1.70 years.After adjusting for potential confounders,the TyG index was positively related to long-term MACE(aHR:1.26,95%CI:1.06-1.49,P=0.009).Conclusions A high TyG index was associated with in-hospital pulmo-nary infection,bleeding,mortality and MACE in patients with STEMI undergoing PCI.Additionally,it is also asso-ciated with long-term MACE.[S Chin J Cardiol 2025;26(1):9-20]
机标关键词：glucoseindexwithassociatedbleedingcoronaryelevationin-hospital
论文发表日期：2025-03-30
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：13( 9-20,35 )
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