Mitral valve regurgitant area as an independent predictor of in-hospital mortality in elderly patients with dilated car-diomyopathy
ZHANG Zi-yi1
LI Xin-yi2
WANG Jia-qi1
GONG Jian-tao1
TAN Ning1
TSANG Suk-Ying2
WONG Wing-tak3
JIANG Lei1
1.Department of Cardiology,Guangdong Cardiovascu-lar Institute,Guangdong Provincial People's Hospital(Guang-dong Academy of Medical Sciences),Southern Medical Univer-sity,Guangzhou 510080,Guangdong,China2.School of Life Sciences,The Chinese University of Hong Kong,Hong Kong SAR,China3.Department of Applied Biology and Chemical Technology,The Hong Kong Polytechnic University,Hung Hom,Hong Kong,China
摘要：Background Predicting in-hospital mortality in elderly patients with dilated cardiomyopathy(DCM)is critical for improving clinical management.This study investigated the prognostic significance of mitral valve regurgitant area(MVRA)as a predictor of in-hospital mortality.Methods A total of 813 elderly patients(age≥60 years)diag-nosed with DCM were included in this retrospective study,with admissions spanning from January 2010 to Decem-ber 2019.Univariate and multivariate Cox regression analyses were conducted to assess the association between MVRA and in-hospital mortality.Receiver operating characteristic(ROC)curve and Kaplan-Meier survival analy-ses were employed to assess the predictive performance of MVRA and to compare cumulative survival rates be-tween groups,respectively.Results MVRA was significantly associated with in-hospital mortality in both univar-iate and multivariate analyses(HR:1.119,95%CI:1.028-1.218,P=0.009).ROC curve analysis demonstrated good prognostic performance for MVRA[area under curve(AUC):0.714].Kaplan-Meier analysis revealed that patients with high MVRA(HMVRA)had significantly worse in-hospital survival outcomes(log-rank χ2=12.628,P<0.001).Conclusions An increase in MVRA is significantly associated with higher in-hospital mortality in elderly DCM patients,with an MVRA exceeding 7 cm2 indicating a notably increased mortality rate.MVRA serves as a simple and effective parameter for risk assessment and treatment monitoring in DCM patients.[S Chin J Cardiol 2025;26(1):42-48]
机标关键词：areawithcar-diomyopathydilatedelderlyin-hospitalindependentmitral
论文发表日期：2025-03-30
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：7( 42-48 )
英文信息