尿酸白蛋白比值与老年心脏瓣膜手术患者长期死亡率呈正相关
WANG Yu-ru
GU Bo-wen
BAO Rong-xing
GU Xiao-lin
HE Hai-lin
Department of Cardiovascular Surgery,Guangdong Provincial People's Hospital,Guangdong Academy of Medical Sciences,Southern Medical University,Guangdong 510180,Guangdong,China
摘要：Background The uric acid to albumin ratio(UAR)has emerged as a potential biomarker for systemic inflam-mation and oxidative stress,both of which are implicated in adverse outcomes following cardiac surgery.This study aimed to explore the association between UAR and long-Term mortality in elderly patients undergoing heart valve surgery.Methods A retrospective cohort study was conducted on 202 elderly patients who underwent valve sur-gery in the Cardiac Surgery Intensive Care Unit(CSICU)between January 2013 and April 2014.Patients were strat-ified into three groups based on UAR level(low:5.66-10.26;middle:10.29-13.47;high:13.48-31.88).The multi-variable cox regression analysis with covariate adjustment and subgroup analyses were performed to evaluate the association between UAR and long-term mortality,with a median follow-up period of 7.9 years.Smooth curve fit-ting was used to evaluate the potential linear association between UAR and long-term follow-up mortality.Ka-plan-Meier curves with log-rank tests were generated to compare survival distributions among UAR groups.Re-sults In multivariate regression models,UAR demonstrated a significant positive association with long-term fol-low-up mortality after comprehensive covariates adjustment.The adjusted hazard ratios(HR)for long-term fol-low-up mortality was 1.22(95%CI:1.10-1.34,P<0.0001)per 1-unit increase in UAR.We further performed ex-ploratory subgroup analyses which confirmed a higher UAR levels were independently associated with a higher risk of mortality.Kaplan-Meier analysis for event-free survival revealed higher occurrence of long-term follow-up mortality in the high UAR group(P=0.013).Conclusions Elevated UAR levels in elderly patients who underwent valvular surgery in the CSICU demonstrated an positivecorrelation with mortality risk.[S Chin J Cardiol 2025;26(2):69-77]
机标关键词：心脏瓣膜手术手术患者长期死亡率白蛋白正相关老年心脏
论文发表日期：2025-06-30
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：10( 69-77,87 )
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