冠状动脉钙化在他汀类药物治疗和主要不良心血管事件中的作用
WU Di
YU Dan-qing
Guangdong Cardiovascular Institute,Guangdong Pro-vincial People's Hospital,Guangdong Academy of Medical Sci-ences,Guangzhou 510180,Guangdong,China
摘要：Background Coronary artery calcification(CAC),a hallmark of atherosclerosis,paradoxically associates with reduced cardiovascular risk under statin therapy despite accelerated calcification progression,prompting this study to explore CAC metrics as potential mediators between statin use and major adverse cardiovascular events(MACE).Methods Clinical data of 246 hospitalized patients who underwent coronary computed tomography an-giography(CCTA)at Guangdong Provincial People's Hospital from January 2023 to June 2023 were retrospective-ly analyzed.Linear regression was used to evaluate the relationship between statin use and CAC parameters.Multi-variable Poisson regression models were applied to explore the associations of statin use and CAC parameters with MACE risk.A mediation analysis was performed to assess the role of CAC parameters in the statin-MACE rela-tionship.Results Statin use was independently associated with increased calcification score(β=0.648,P<0.001),CAC volume(β=0.623,P<0.001),and calcified plaque proportion(β=0.606,P=0.002).Multivariable Poisson re-gression indicated that statin use significantly reduced MACE risk[incidence rate ratio(IRR):0.33,P=0.018],whereas calcification score(IRR:2.63,P=0.026)and CAC volume(IRR:2.66,P=0.044)were associated with elevat-ed MACE risk;Calcified plaque proportion showed no significant association.Mediation analysis revealed that calcification score(β=0.035,P=0.021)and CAC volume(β=0.023,P=0.018)exerted masking effects,while calci-fied plaque proportion had no mediating role.Conclusions Calcification score and CAC volume demonstrated limit-ed masking effects in the association between statin use and MACE.[S Chin J Cardiol 2025;26(2):78-87]
机标关键词：主要不良心血管事件冠状动脉钙化他汀类药物治疗
论文发表日期：2025-06-30
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：10( 78-87 )
英文信息