N末端脑钠肽前体对感染性心内膜炎合并脓毒症患者短期死亡率的预测价值
WANG Na
XIE Yin-jun
LIAO You-wan
ZHAN Xiu-jin
Department of Geriatric Intensive Medicine,Guang-dong Provincial Geriatrics Institute,Guangdong Provincial Peo-ple's Hospital,Guangdong Academy of Medical Sciences,Southern Medical University,Guangzhou 510080,China
摘要：Background Elevated N-terminal pro-brain natriuretic peptide(NT-pro-BNP)is a recognized predictor of poor prognosis in heart failure and infectious diseases.We aimed to investigate its predictive value for short-term mortality in patients with infective endocarditis(IE)complicated by sepsis.Methods A total of 416 consecutive patients diagnosed with IE and sepsis at Guangdong Provincial People's Hospital were enrolled.The patients were divided into three groups according to the tertiles of NT-pro-BNP level of the first blood collection within 24 hours after admission:<2000 pg/mL(n=138),2000-7167 pg/mL(n=140),and>7167 pg/mL(n=138).Univariate and mul-tivariate regression analysis were used to explore the predictive value of NT-pro-BNP for short-term mortality,and the best cut-off value was determined by receiver operating characteristic(ROC)curve.Results In-hospital and 6-month death occurred in 65 and 94 patients,respectively.Higher in-hospital mortality was found in patients with higher serum NT-pro-BNP levels(9.4%vs.13.6%vs.23.9%,P=0.003).ROC curve analysis identified an optimal NT-pro-BNP cutoff level of 1357 pg/mL[area under curve(AUC):0.652,95%CI:0.588-0.717,P<0.001].Multi-variate regression analysis showed that both log-transformed NT-pro-BNP(in-hospital mortality:OR:1.987,95%CI:1.045-3.778,P=0.036;6-month mortality:HR:1.714,95%CI:1.072-2.7400,P=0.025)and NT-pro-BNP>1357 pg/mL(in-hospital mortality:OR:8.059,95%CI:1.813-35.818,P=0.006;6-month mortality:HR:5.193,95%CI:1.806-14.938,P=0.002)were both independent risk factors for in-hospital and 6-month mortality.Conclu-sions Serum NT-pro-BNP could serve as an independent predictor of in-hospital and 6-month mortality in pa-tients with IE complicated with sepsis.[S Chin J Cardiol 2025;26(2):121-127]
机标关键词：n末端脑钠肽前体感染性心内膜炎脓毒症患者死亡率预测价值短期死亡
论文发表日期：2025-06-30
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：8( 121-127,封3 )
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