Apolipoprotein E and coronary artery disease: the debate is still on
Liang Ge
Thach Nguyen
摘要： Apolipoprotein E (Apo E) is quite a fascinating lipoprotein. As reported by Zou et al. 1 in this issue of the Journal of Geriatric Cardiology, Apo E has three isoforms,ε2, ε3, and ε4, differing from each other by the polymorphisms found in the amino acid residues at sites 112 and 158. Apo E and its three isoforms, with ε3 being the most common, is like a Pandora's box of sorts, where upon investigation, interesting correlations to some very prominent modem diseases have been found. For example, there was evidence that the presence of one ε4 allele in their Apo E gene increased the risk for type-2Alzheimer's disease and two ε4 alleles would increase further this risk. Also intriguing is the subject of this paper by Zou et al.: the relationship between Apo E isoform ε2 and the presence of coronary artery disease (CAD).
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分类号：R5(内科学)
论文发表日期：2006-04-02
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：1( 99 )