Atrial fibrosis: an obligatory component of arrhythmia mechanisms in atrial fibrillation?
Pyotr G Platonov
摘要：Atrial fibrosis is common in atrial fibrillation (AF).Experimental studies have provided convincing evidence that fibrotic transformation of atrial myocardium results in deterioration of atrial conduction,increasing anisotropy of impulse propagation and building of boundaries that promote re-entry in the atrial walls that maybe directly relevant for the mechanisms responsible for maintaining AF.Whether or not fibrosis is a result of structural remodelling caused by persistent AF or a manifestation of occult myocardial process that leads to development of arrhythmia is less clear.Human data indicate the presence of association between persistency of AF and the extent of structural changes in atrial myocardium.The role atrial fibrosis plays in the mechanisms of AF,however,may differ between patients with structurally normal hearts,such as lone AF,and those with advanced cardiovascular comorbidities.
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论文发表日期：2017-10-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：5( 233-237 )
英文信息