Prognostic utility of NT-proBNP greater than 70,000 pg/mL in patients with end stage renal disease
Julio Perez-Downes
Carlos Palacio
Saif Ibrahim
Patrisha Shelley
Alan Miller
Pramod Reddy
摘要：Natriuretic peptides are synthesized in ventricular myocytes and released into the circulation in response to increased myocardial wall stress.[1] Causes of myocardial wall stress include pulmonary hypertension,ventricular dilatation,as well as heart failure with reduced or preserved left ventricular function.[1] The 108 amino acid pro-brain natriuretic peptide (pro-BNP) is the cleavage product of the 134-amino acid hormone Pre-Pro-BNP,[2] which once released into circulation it further cleaves into C-terminal pro-BNP (32 amino acids,BNP) and N-terminal pro-BNP (76 amino acids,NT-proBNP).[3,4] Physiological effects of pro-BNP include reduction of sympathetic tone and activity of the renin-angiotensin system,promotion of vasodilation,natriuresis and diuresis.[5]
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论文发表日期：2018-07-19
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：3( 476-478 )
英文信息