Correction of hypovitaminosis D improved global longitudinal strain earlier than left ventricular ejection fraction in cardiovascular older adults after orthopaedic surgery
Matteo Briguglio
Luigi Gianturco
Daniele Stella
Chiara Colombo
Marika Bonadies
Oscar Sala
Mauro Anselmi
Giuseppe Banfi
Maurizio Turiel
摘要：Background Cardiovascular diseases and insufficient levels of vitamin D are risk factors for adverse surgical outcomes,and they are both commonly present among older adults undergoing orthopaedic surgery.Giving the cardiovascular effects of vitamin D,pre-operative diagnosis of hypovitaminosis D would be a valuable step for the implementation of supplementation protocols.We investigated if the normalization of serum 25 [OH] D could ameliorate cardiac performance of older adults suffering from cardiovascular diseases.Methods We enrolled 47 older adults scheduled for major orthopaedic surgery and suffering from hypovitaminosis D.Patients underwent 6-months calcifediol supplementation with a starting dose at first post-operative day of 50 tg/die in liquid preparation.Down-titration to 20 μg/die at 3-months assessment was planned.Cardiac performance was evaluated by measuring left ventricular ejection fraction (LVEF) and global longitudinal strain (GLS) during pre-operative assessments and at 1-month,3-months,6-months follow-ups.Results Six months of calcifediol supplementation were associated with a significant improvement of both LVEF (+ 3.94％;95％ CI:-4.0789 to-0.8232;P ＜ 0.01) and GLS (+ 18.56％;Z =-5.895;P ＜ 0.0001).Conclusions Calcifediol supplementation normalized serum 25 [OH] D concenwation after 1-month treatment.GLS offered better insights into myocardial contractile amelioration than LVEF,thus being useful for detecting earlier subclinical changes that may anticipate hemodynamic modifications.
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论文发表日期：2018-08-21
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：4( 519-522 )
英文信息