Five-year major clinical outcomes between first-generation and second-generation drug-eluting stents in acute myocardial infarction patients underwent percutaneous coronary intervention
Yong Hoon Kim
Ae-Young Her
Seung-Woon Rha
Byoung Geol Choi
Se Yeon Choi
Jae Kyeong Byun
Ju Yeol Baek
Woong Gil Choi
Tae Soo Kang
Ji Hoon Ahn
Sang-Ho Park
Ahmed Mashaly
Jin Oh Na
Cheol Ung Choi
Hong Euy Lim
Eung Ju Kim
Chang Gyu Park
Hong Seog Seo
Dong Joo Oh
摘要：Background There were limited data comparing the major clinical outcomes between first-generation (1G)-drug eluting stents (DES) and second-generation (2G)-DES in patients with acute myocardial infarction (AMI) after percutaneous coronary intervention (PCI) during very long follow-up periods.We thought to investigate the comparative efficacy and safety of 2G-DES compared with 1G-DES in AMI patients during 5-year follow-up periods.Method A total of 1016 eligible AMI patients who underwent PCI with 1G-DES [paclitaxel-,sirolimus-,1G-zotarolimus-eluting stent (endeavor(R) or endeavor sprint(R)),n =554] or 2G-DES [2G-zotarolimus (endeavor resolute(R))-or everolimus-eluting stent,n =462] were enrolled.The primary endpoint was the occurrence of major adverse cardiac events (MACE) defined as total death,non-fatal myocardial infarction (MI),target lesion revascularization (TLR),target vessel revascularization (TVR),non-target vessel revascularization (Non-TVR) and the secondary endpoint was stent thrombosis (ST) at 5 years.Results Two propensity score-matched (PSM) groups (232 pairs,n =464,C-statistic =0.802) were generated.During the 5-year follow-up period,the cumulative incidence of TLR [hazard ratio (HR):3.133;95％ confidence interval (CI):1.539-6.376;P =0.002],TVR (HR:3.144;95％ CI:1.596-6.192;P =0.001) and total revascularization rate (HR:1.874;95％ CI:1.086-3.140;P =0.023) were significantly higher in 1G-DES compared with 2G-DES after PSM.However,the incidence of total death,non-fatal MI and ST were similar between the two groups.Conclusion In this single-center and all-comers registry,2G-DES's superiorities for TLR,TVR and total revascularization in AMI patients suggested during 5-year clinical follow-up periods.
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论文发表日期：2018-08-21
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：11( 523-533 )
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