Normalization of plasma growth hormone alleviated malignant ventricular tachycardia in acromegaly
Zhi-Hao LIU
Kang LI
Yan-Sheng DING
Jian-Xing QIU
Steven Siyao Meng
Mohetaboer Momin
Sheng-Cong LIU
Tie-Ci YI
Jian-Ping LI
摘要：Acromegaly is an insidious endocrine disease characterized by chronic elevation of growth hormone (GH) and insulin-like growth factor-1 (IGF-1).[1] Persistent excess secretion of GH and IGF-1 damages both cardiac structure and function,leading to acromegalic cardiomyopathy,which is one of the most common causes of increased mortality in acromegaly and can result in an average of 10-year reduction in life expectancy.[2,3] In patients with acromegaly,approximately 3％ have been reported having a unique cardiomyopathy characterized by biventricular hypertrophy,myocardial necrosis,lymphocytic infiltration,interstitial fibrosis.[4] The manifestations of acromegalic cardiomyopathy include systolic or diastolic cardiac dysfunction as well as fatal arrhythmias.[5,6] This case report focuses on ventricular tachycardia (VT) in a patient with acromegaly.After normalization of plasma GH levels with therapy,ventricular tachycardia was resolved.
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论文发表日期：2018-08-21
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：4( 547-550 )
英文信息