Incremental age-related one-year MACCE after acute myocardial infarction in the drug-eluting stent era (from KAMIR-NIH registry)
Dae-Won Kim
Sung-Ho Her
Ha Wook Park
Kiyuk Chang
Wook Sung Chung
Ki Bae Seung
Myung Ho Jeong
Hyo-Soo Kim
Hyeon Cheol Gwon
In Whan Seong
Kyung Kuk Hwang
Shung Chull Chae
Kwon-Bae Kim
Young Jo Kim
Kwang Soo Cha
Seok Kyu Oh
Jei Keon Chae
Ji-Hoon Jung
摘要：Objectives To evaluate the age-related one-year major adverse cardiocerebrovascular events (MACCE) after percutaneous coronary intervention (PCI) in acute myocardial infarction (AMI).We analyzed the association between age and one-year MACCE after AMI.Methods A total of 13,104 AMI patients from Korea Acute Myocardial Infarction Registry-National Institue of Health (KAMIR-NIH)between November 2011 and December 2015 were classified into four groups according to age (Group Ⅰ,＜ 60 years,n =4199;Group Ⅱ,60-70 years,n =2577;Group Ⅲ;70-80 years,n =2774;Group Ⅳ,＞ 80 years,n =1018).Patients were analyzed for one-year composite of MACCE (cardiac death,myocardial infarction,target vessel revascularization,cerebrovascular events) after AMI.Results The one-year MACCE in AMI were 3.5％ (Group Ⅰ),6.3％ (Group Ⅱ),9.6％ (Group Ⅲ) and 17.6％ (Group Ⅳ).After adjustment for confounding parameters,the analysis results showed that patients with AMI had incremental risk of one-year MACCE [Group Ⅱ,adjusted hazard ratios (aHR)=1.224,95％ CI:0.965-1.525,P =0.096;Group Ⅲ,aHR =1.316,95％ CI:1.037-1.671,P=0.024;Group Ⅳ,aHR =1.975,95％ CI:1.500-62.601,P ＜ 0.001) compared to Group Ⅰ.Especially,cardiac death in the composite of primary end point played a major role in this effect (Group Ⅱ,aHR =1.335,95％ CI:0.941-1.895,P=0.106;Group Ⅲ,aHR =1.575,95％ CI:1.122-2.210,P=0.009;Group Ⅳ,aHR =2.803,95％ CI:1.937-4.054,P ＜ 0.001).Conclusions Despite advanced techniques and medications for PCI in AMI,age still exerts a powerful influence in clinical outcomes.Careful approaches,even in the modern era of developed cardiology are needed for aged-population in AMI intervention.
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论文发表日期：2018-09-23
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：11( 574-584 )
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