Characterization of coronary atherosclerotic plaques in a homozygous familial hypercholesterolemia visualized by optical coherence tomography
Ze-Sen LIU
Jie PENG
Shi-Long WANG
Tao JIANG
Jie LIN
Kang MENG
摘要：Familial hypercholesterolemia (FH) is an autosomal dominant genetic disorder,which resulted in severe elevations in low-density lipoprotein cholesterol (LDL-C) and a markedly increased risk of early-onset coronary disease.[1] It is most frequently caused by loss-of-function mutations in genes affecting the LDL receptor,which clears LDL particles from plasrna.[2] FH accelerates atherosclerotic cardiovascular disease,especially coronary heart disease,with clinical manifestations often occurring after one to four decades of life.[3] The untreated patients with homozygous familial hypercholesterolemia (HoFH),which is caused by mutations in both alleles of the gene encoding the LDL receptor,developed overt atherosclerosis before the age of 20 years and generally do not survive past 30 years.Intravascular optical coherence tomography (OCT) has been proposed as a high-resolution imaging method for characterization of coronary atherosclerotic plaques.[4] Its utility in the evaluation of plaque composition can provide insights into the pathology of coronary arteries abnormalities.[5] However,little information about coronary atherosclerotic plaques of patients with FH has been presented.
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论文发表日期：2018-11-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：6( 738-743 )
英文信息