Protective effect of Danhong injection in patients with acute myocardial infarction at a high risk of no-reflow during primary percutaneous coronary intervention
Qi YOU
Jing WANG
Wei DONG
Feng TIAN
Hong-Xu LIU
Jing JING
Yun-Dai CHEN
摘要：Objective To observe the effect of Danhong injection (DI) in patients with acute ST-segment elevation myocardial infarction (STEMI) at a high risk ofno-reflow (NR) during primary percutaneous coronary intervention (PCI).Methods Patients were placed in a DI group and control group.The DI group was given DI and the control group was given physiologic saline.The administration lasted 4 to 6 days in both groups after PCI.Cardiac magnetic resonance (CMR) was carried out during the perioperative period (7 ± 2 days).The primary endpoint of the study was myocardial infarct size (IS) imaged on delayed-enhancement CMR.The secondary endpoint was major adverse cardiac events observed 6 months after PCI.Results In total,160 high-risk NR patients were enrolled,and 110 patients completed the CMR examination.According to postoperative CMR,the Myocardial Salvage Index and left ventricular ejection fraction were higher in the DI group (0.57 ± 0.13 vs.0.48 ± 0.17,P ＜ 0.01;49.3％ ± 6.9％ vs.46.2％ ± 7.7％,P =0.03,respectively),whereas the IS was lower (19.7％ ± 5.6％ vs.22.2％ ± 6.5％,P =0.04),compared with that in the control group.These differences were observed to be significant.After 6 months,the prevalence of major adverse cardiac events in the DI group decreased compared with that in the control group,but the differences were not observed to be significant (P ＞ 0.05).Conclusion The application of DI can reduce the myocardial infarct size in STEMI patients at a high risk of NR during primary PCI.
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论文发表日期：2019-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：8( 406-413 )
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