Calcium channel blocker monotherapy versus combination with renin-angiotensin system inhibitors on the development of new-onset diabetes mellitus in hypertensive Korean patients
Yong Hoon Kim
Ae-Young Her
Seung-Woon Rha
Byoung Geol Choi
Se Yeon Choi
Jae Kyeong Byun
Yoonjee Park
Dong Oh Kang
Won Young Jang
Woohyeun Kim
Woong Gil Choi
Tae Soo Kang
Jihun Ahn
Sang-Ho Park
Ji Young Park
Min-Ho Lee
Cheol Ung Choi
Chang Gyu Park
Hong Seog Seo
摘要：Background In real practice,two or more antihypertensive drugs are needed to achieve target blood pressure.We investigated the comparative beneficial actions of combination therapy of renin-angiotensin system inhibitors (RASI),with calcium channel blockers (CCB)over CCB monotherapy on the development of new-onset diabetes mellitus (NODM) in Korean patients during four-year follow-up periods.Methods A total of 3208 consecutive hypertensive patients without a history of diabetes mellitus who had been prescribed CCB were retrospectively enrolled from January 2004 to December 2012.These patients were divided into the two groups according to the additional use of RASI (the RASI group,n =1221 and the no RASI group,n =1987).Primary endpoint was NODM,defined as a fasting blood glucose ≥126 mg/dL or hemoglobin Alc ≥ 6.5％.Secondary endpoint was major adverse cardiac events (MACE) defined as total death,myocardial infarction (MI) and percutaneous coronary intervention (PCI).Results After propensity score-matched (PSM) analysis,two propensity-matched groups (939 pairs,n =1878,C-statistic =0.743) were generated.The incidences ofNODM (HR =1.009,95％ CI:0.700-1.452,P =0.962),MACE (HR =0.877,95％ CI:0.544-1.413,P =0.589),total death,MI,PCI were similar between the two groups after PSM during four years.Conclusions The use of RASI in addition to CCB showed comparable incidences of NODM and MACE compared to CCB monotherapy in non-diabetic hypertensive Korean patients during four-year follow-up period.However,large-scaled randomized controlled clinical trials will be required for a more definitive conclusion.
机标关键词：
论文发表日期：2019-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：9( 439-447 )
英文信息