Predictors of non-response to cardiac resynchronization therapy implantation in patients with class Ⅰ indications: the markedly dilated left ventricular end-diastolic dimension and the presence of fragmented QRS
Yi-Ran HU
Wei HUA
Sheng-Wen YANG
Min GU
Hong-Xia NIU
Li-Gang DING
Jing WANG
Ran JING
Xiao-Han FAN
Shu ZHANG
摘要：Background Cardiac resynchronization therapy (CRT) is a highly effective treatment in patients with a class Ⅰ recommendation.However,a small proportion of the strictly selected patients still fail to respond.This study was designed to identify predictors of non-response in patients with class Ⅰ indications for CRT and determine the non-response probability of the patients.Methods A total of 296 consecutive patients with a class Ⅰ recommendation received CRT from January 2009 to January 2017 were retrospectively analyzed.Multivariate logistic regression analysis was performed to identify predictors for non-response (defined as cardiac death,heart transplantation,or HF hospitalization during 1-year follow-up).Results Among 296 patients,30 (10.1％) met non-response.Multivariate analysis demonstrated that non-response to CRT was associated with a fragmented QRS (odd ratio (OR) =2.86,95％ CI:1.14-7.12;P =0.025) and left ventricular end-diastolic dimension (LVEDD) ≥ 77 mm (OR =3.02,95％ CI:1.17-7.82;P =0.022).Patients with both of the predictors had a non-response probability of 46.2％ (95％ CI:19.1％-73.3％).Conclusion In patients with left bundle branch block and wider QRS duration,the proportion of non-response to CRT is not low in real world.The presence of the dilated LVEDD or fragmented QRS is a strong predictor of non-response to CRT.The probability of non-response in the patients with the two predictors was 46.2％.
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论文发表日期：2019-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：8( 514-521 )
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