Five-year clinical outcomes of first-generation versus second-generation drug-eluting stents following coronary chronic total occlusion intervention
Yong Hoon Kim
Ae-Young Her
Seung-Woon Rha
Byoung Geol Choi
Se Yeon Choi
Jae Kyeong Byun
Yoonjee Park
Dong Oh Kang
Won Young Jang
Woohyeun Kim
Ju Yeol Baek
Woong Gil Choi
Tae Soo Kang
Jihun Ahn
Sang-Ho Park
Ji Young Park
Min-Ho Lee
Cheol Ung Choi
Chang Gyu Park
Hong Seog Seo
摘要：Background There are limited data comparing long-term clinical outcomes between first-generation (1 G) and second-generation (2G) drug-eluting stents (DESs) in patients who underwent successful percutaneous coronary intervention (PCI) for coronary chronic total occlusion (CTO) lesion.Methods A total of 840 consecutive patients who underwent PCI with DESs for CTO lesion from January 2004 to November 2015 were enrolled.Finally,a total of 324 eligible CTO patients received 1G-DES (Paclitaxel-eluting stent or Sirolimus-eluting stent,n =157) or 2G-DES (Zotarolimus-eluting stent or Everolimus-eluting stent,n =167) were enrolled.The clinical endpoint was the occurrence of major adverse cardiac events (MACE) defined as all-cause death,recurrent myocardial infarction (re-MI),total repeat revascularization [target lesion revascularization (TLR),target vessel revascularization (TVR),and non-TVR].We investigated the 5-year major clinical outcomes between 1G-DES and 2G-DES in patient who underwent successful CTO PCI.Results After propensity score matched (PSM)analysis,two well-balanced groups (111 pairs,n =222,C-statistic =0.718) were generated.Up to the 5-year follow-up period,the cumulative incidence of all-cause death,re-MI,TLR,TVR and non-TVR were not significantly different between the two groups.Finally,MACE was also similar between the two groups (HR =1.557,95％ CI:0.820-2.959,P =0.176) after PSM.Conclusions In this study,2G-DES was not associated with reduced long-term MACE compared with 1G-DES following successful CTO revascularization up to five years.
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论文发表日期：2019-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：9( 639-647 )
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