Qishen capsule safely boosts cardiac function and angiogenesis via the MEK/ERK pathway in a rat myocardial infarction model
Cai-Xia GUO
Zhi-Yuan LI
Jin-Bang NIU
Shuan-Cheng FAN
Si-Yu YAN
Pei-Pei LU
Yan-Ni SU
Li-Hong MA
摘要：Background Qishen (QS) capsules,a Traditional Chinese Medicine,has been widely used to treat coronary heart disease in China.However,evidence of its effectiveness remains unclear.Methods To explore whether QS has cardioprotective efficacy and/or promotes angiogenesis after myocardial infarction (MI),we performed experiments in a preclinical rat MI model.One month after left anterior descending coronary artery ligation,the rats received either QS solution (0.4 g/kg/day) or the same volume of saline by intragastric injection for four weeks.Results Echocardiographic and hemodynamic analyses demonstrated relatively preserved cardiac function in MI rats administered QS.Indeed,QS treatment was associated with reduced infarct scar size and heart weight index,and these beneficial effects were responsible for enhancing angiogenesis.Mechanistically,QS treatment increased phosphorylation of protein kinase B (Akt) and downregulated phosphorylation ofmitogen-activated protein kinase/extracellular-regulated kinase (MEK/ERK).Conclusions QS therapy can improve the cardiac function of rats after MI by an underlying mechanism involving increased angiogenesis,at least partially via activation of the Akt signaling pathway and inhibition of MEK/ERK phosphorylation.
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论文发表日期：2019-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：11( 764-774 )
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