Association between big endothelin-1 and CHADS2/CHA2DS2-VAsc scores in non-valvular atrial fibrillation
Li-Hui ZHENG
Shang-Yu LIU
Feng HU
Er-Peng LIANG
Ling-Min WU
Hong-Lei WANG
Ammar M Killu
Yan YAO
摘要：Background Endothelial function,as measured by big endothelin-1(ET-1),has been demonstrated to be useful in predicting adverse long-term events in patients with cardiovascular disease.Nevertheless,there are little data about the association between big ET-1 and thromboembolism risk in atrial fibrillation(AF).We aimed to investigate the relationship between big ET-1 and CHADS2/CHA2DS2-VASc scores used for evaluating thromboembolic risk in patients with non-valvular AF.Methods The study population consisted of 238 consecutive AF patients(67.6％with paroxysmal AF and 32.4％with persistent AF).The patients were divided into two groups(high-or low-intermediate risk group)based on CHADS2 and CHA2DS2-VASc scores(score≥2 or ＜ 2,respectively).Clinical,laboratory,and echocardiographic parameters were evaluated,and the CHADS2/CHA2DS2-VASc scores were compared between groups.The association between big ET-1 levels and CHADS2/CHA2DS2-VASc score was assessed.Multivariate logistic regression analysis was performed to identify independent predictors of CHADS2/CHA2DS2-VASc scores.Results The high CHADS2/CHA2DS2-VASc score group had older age,higher big ET-1 levels,and enlarged left atrial diameter than the low CHADS2/CHA2DS2-VASc score group(P ＜ 0.05).Multiple logistic regression analysis revealed that big ET-1 level was an independent determinant of high CHADS2/CHA2DS2-VASc scores [odds ratio(OR)= 2.545 and OR = 3.816 ; both P ＜0.05].Conclusions Our study indicates that in non-valvular AF,big ET-1 was significantly correlated with CHADS2/CHA2DS2-VASc scores and an independent predictor of high CHADS2/CHA2DS2-VASc scores.Big ET-1 may serve as a useful marker for risk stratification in this setting.
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论文发表日期：2019-11-28
页数：6( 812-817 )
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